CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA

Authors

  • Sarma LUMBANRAJA Universitas Sumatera Utara
  • Iman Helmy EFFENDI Universitas Sumatera Utara https://orcid.org/0000-0002-3147-9857
  • Andre M SIAHAAN Neurosurgery Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
  • Berry E P BANCIN Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
  • Deri EDIANTO Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
  • Edwin Martin ASROEL Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.
  • Yudha SUDEWO Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Sumatera Utara, Medan, 20136, Indonesia.

DOI:

https://doi.org/10.21010/Ajidv17i1.4

Keywords:

COVID-19, SARS-CoV-2, Coronavirus, Pandemic, Pathogenesis, Placenta, pregnancy, mother to child transmission, Preeclampsia, SAR-CoV-2, IHC, Nucleocapsid, Histopathology.

Abstract

Background: The pandemic caused by SARS-CoV-2 also caused infection in some pregnant women. Some reports say this viral infection can show symptoms of preeclampsia.

Material and Methods: We analyzed 25 pregnant women with SARS-CoV-2 infection with 4 patients presenting with symptoms of preeclampsia. we performed routine blood analysis, renal function, liver function, and IHC examination to see the expression of viral proteins in the placenta.

Results: we obtained 4 patients with confirmed SARS-CoV-2 infection by RT-PCR. In these 4 cases, none of the cases showed expression of the SARS-CoV-2 viral protein in the placenta, and all 4 mothers were declared dead after treatment, and 2 babies delivered out of these 4 cases died. In one case we had fetal death in pregnancy while in one case prematurity. 2 babies born to mothers with SARS-CoV-2 infection with preeclampsia were born in good condition. There were no babies infected with SARS-CoV-2

Conclusion: We conclude that SAR-CoV-2 infection in pregnant women with comorbidities can lead to a poor prognosis for both mother and baby. We cannot yet conclude whether SARS-CoV-2 infection can cause preeclampsia, but SARS-CoV-2 infection can exacerbate preeclampsia symptoms.

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Published

2022-12-22

How to Cite

LUMBANRAJA , S., EFFENDI, I. H., SIAHAAN , A. M., BANCIN, B. E. P., EDIANTO, D. ., ASROEL , E. M. ., & SUDEWO , Y. . (2022). CORRELATION OF SARS-COV-2 EXPRESSION IN THE PLACENTA AND THE INCIDENCE OF PREECLAMPSIA. African Journal of Infectious Diseases (AJID), 17(1), 45–54. https://doi.org/10.21010/Ajidv17i1.4

Issue

Vol. 17 No. 1 (2023)

Section

Articles

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