PRELIMINARY IN VITRO ANTISICKILNG PROPERTIES OF CRUDE JUICE EXTRACTS OF PERSIA AMERICANA, CITRUS SINENSIS, CARICA PAPAYA AND CIKLAVIT®.

Authors

  • E. E. Iweala
  • F. O. Uhegbu
  • G. N. Ogu

Keywords:

Antisickling, Ciklavit®, Persia americana, Citrus sinensis, Carica papaya

Abstract

The antisickling properties of crude juice extracts of the edible portions of three commonly consumed tropical fruits namely Persia americana, Citrus sinensis, and Carica papaya were investigated in vitro alongside a new drug preparation called Ciklavit® that has antisickling activity. Four different solvent extracts of the crude juice of each fruit including aqueous, acidic, alkaline and alcoholic extracts were prepared and their antisickling effects on sickle cell trait (HbAS) and sickle cell disease (HbSS) blood samples checked alongside Ciklavit®. Blood samples were stabilized using normal saline and the antisickling effects were checked by counting the number of sickle cells remaining after incubation of the blood samples with the crude fruit extracts and Ciklavit® for twenty-four hours. The results showed that Ciklavit® produced a sustained reduction in the number of sickle cells in both HbAS and HbSS blood samples. Also the alkaline and alcoholic extracts of P. americana and C. papaya produced significant reduction in the number of sickle cells.

Author Biography

E. E. Iweala

Department of Biological Sciences, Covenant University, Ota, Nigeria

Downloads

Published

2009-11-12

How to Cite

Iweala, E. E., Uhegbu, F. O., & Ogu, G. N. (2009). PRELIMINARY IN VITRO ANTISICKILNG PROPERTIES OF CRUDE JUICE EXTRACTS OF PERSIA AMERICANA, CITRUS SINENSIS, CARICA PAPAYA AND CIKLAVIT®. African Journal of Traditional, Complementary and Alternative Medicines, 7(2), 113–117. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1039

Issue

Vol. 7 No. 2 (2010)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.