(4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA

Authors

  • C. C. Joseph
  • M. J. Moshi
  • J. Sempombe
  • M. H. H. Nkunya

Keywords:

Securidaca longepedunculata, Antimicrobial, Benzophenone, (4-Methoxy-benzo[1, 3]dioxol-5-yl)-phenylmethanone

Abstract

The dichloromethane extract of Securidaca longepedunculata Fresen yielded a benzophenone, (4-methoxy-benzo[1,3]dioxol-5-yl)-phenylmethanone (1), together with other three known compounds, 1,7-dihydroxy-4-methoxyxanthone (2), benzyl 2-hydroxy-6-methoxybenzoate (3), and methyl 2-hydroxy-6-methoxybenzoate (4). Compound (1) exhibited antibacterial activity against Pseudomonous aeruginosa, and antifungal activity against Aspergillus fumigatus. Compound 2 exhibited antibacterial activity against Staphylococus aureus, and antifungal activity against Aspergillus niger, Aspergillus fumigatus and a Penicillum species. Compounds 3 and 4 were inactive against all the tested bacteria and fungi. These results provide proof of efficacy of the extracts of S.longepedunculata in treating bacterial infections, but further studies should be carried out to ascertain these results with respect to the widely reported traditional use.

Author Biographies

C. C. Joseph

Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania

M. J. Moshi

Institute of Traditional Medicine, Muhimbili University College of Health Sciences, University of Dar es Salaam, P.O. Box 65001, Dar es Salaam, Tanzania

J. Sempombe

Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania

M. H. H. Nkunya

Department of Chemistry, University of Dar es Salaam, P.O. Box 35061, Dar es Salaam, Tanzania

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Published

2006-03-27

How to Cite

Joseph, C. C., Moshi, M. J., Sempombe, J., & Nkunya, M. H. H. (2006). (4-METHOXY-BENZO[1,3]DIOXOL-5-YL)-PHENYLMETHANONE: AN ANTIBACTERIAL BENZOPHENONE FROM SECURIDACA LONGEPEDUNCULATA. African Journal of Traditional, Complementary and Alternative Medicines, 3(3), 80–86. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/106

Issue

Vol. 3 No. 3 (2006)

Section

Research Papers

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