ANTHELMINTHIC EFFICACY OF AQUEOUS EXTRACT OF ACANTHUS MONTANUS LEAF AGAINST STRONGYLID NEMATODES OF SMALL RUMINANTS

Authors

  • M. Adamu Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.
  • O. D. Oshadu Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.
  • C. I. Ogbaje Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

Keywords:

Anthelminthic, Extract, Strongylid Nematodes, Acanthus montanus

Abstract

The anthelminthic efficacy of the crude aqueous extract of Acanthus montanus (Nees) T. Anders (Acanthaceae) against strongylid nematodes of small ruminants was investigated using the in-vitro egg hatch and larval growth inhibition assays. Faecal samples collected per rectum from sheep and goats were subjected to parasitological examination using the McMaster counting technique with a yield of 700 eggs per gram (E.P.G.) of faeces. Crude aqueous leaf extract of Acanthus montanus was extracted using cold water extraction with a yield of 13.01% w/w. Egg hatch assay revealed a 91.75% reduction in egg hatch at concentration of 25mg/ml of the extract. The extract had a 100% inhibition, at 200mg/ml concentration which was equivalent to the activity of 3.125mg/ml albendazole. The distilled water control however, showed a 0% inhibition. Larval growth inhibition assay results showed the extract on Day 1 at 25mg/ml and 200mg/ml concentrations yielded 67.02% and 85.26% larval inhibition. On Day 2, 100% inhibition was obtained on all concentrations of the extract except for 25mg/ml that yielded 88.30%. Albendazole however, had a 100% larval inhibition for all concentrations on Day 2. A 100% larval inhibition was recorded on Day 3 from the 25mg/ml concentrations. The mean percentage larval inhibition of the extract at 200mg/ml (92.63%) was comparable to the standard anthelminthic (albendazole) at 12.50mg/ml (92.28%). These findings showed that there is a pharmacological basis for the folkloric claim of the anthelminthic effect of Acanthus montanus.

Author Biographies

M. Adamu, Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

O. D. Oshadu, Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

C. I. Ogbaje, Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

Department of Veterinary Parasitology and Entomology, College of Veterinary Medicine University of Agriculture, PMB 2373 Makurdi, Nigeria.

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Published

2010-04-09

How to Cite

Adamu, M., Oshadu, O. D., & Ogbaje, C. I. (2010). ANTHELMINTHIC EFFICACY OF AQUEOUS EXTRACT OF ACANTHUS MONTANUS LEAF AGAINST STRONGYLID NEMATODES OF SMALL RUMINANTS. African Journal of Traditional, Complementary and Alternative Medicines, 7(4), 279–285. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1095

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Section

Research Papers