PROTECTIVE EFFECTS OF MOUTAN CORTEX RADICIS AGAINST ACUTE HEPATOTOXICITY

Authors

  • Juhyun Park Sungkyunkwan University
  • Hyo-Yeon Kim Sungkyunkwan University
  • Sun-Mee Lee Sungkyunkwan University

Keywords:

carbon tetrachloride, D-galactosamine, inflammation, Moutan Cortex Radicis, α-naphthylisothiocyanate

Abstract

This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl4)-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl4 (10 μL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally at 48, 24, and 2 h before and 6 h after administration of CCl4, GalN, and ANIT. Serum activities of aminotransferase were significantly higher at 24 h after CCl4 or GalN treatment. These changes were attenuated by MCR. Histopathological analysis revealed multiple and extensive areas of portal inflammation, hepatocellular necrosis, and an increase in inflammatory cell infiltration. These changes were inhibited by MCR. Serum total bilirubin concentration increased and bile flow decreased significantly 48 h after ANIT treatment, which was attenuated by MCR. Our results suggest that MCR has a protective effect on acute liver injury.

Author Biographies

Juhyun Park, Sungkyunkwan University

School of Pharmacy

Hyo-Yeon Kim, Sungkyunkwan University

School of Pharmacy

Sun-Mee Lee, Sungkyunkwan University

School of Pharmacy

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Published

2011-05-09

How to Cite

Park, J., Kim, H.-Y., & Lee, S.-M. (2011). PROTECTIVE EFFECTS OF MOUTAN CORTEX RADICIS AGAINST ACUTE HEPATOTOXICITY. African Journal of Traditional, Complementary and Alternative Medicines, 8(5S), 220–225. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1189

Issue

Vol. 8 No. 5S (2011)

Section

Research Papers

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