PRELIMINARY EVALUATION OF THE WOUND HEALING EFFECT OF VITEX DONIANA SWEET (VERBENACEAE) IN MICE.

Authors

  • kossi Amegbor Université de Lomé
  • Koffi Metowogo Université de Lomé
  • Kwashi Eklu-Gadegbeku Université de Lomé
  • Amegnona Agbonon Université de Lomé
  • Kodjo Amedonou Aklikokou Université de Lomé
  • Gado Napo-koura Université de Lomé
  • Messanvi Gbeassor Université de Lomé

Keywords:

Vitex doniana, wound healing, inflammation, histology

Abstract

Vitex doniana is traditionally used in Togo to treat various diseases including wounds. The aim of this work was to evaluate the efficiency of Vitex doniana on cutaneous wound healing. Wounds were induced in ICR mice divided into four groups as following: Group I received carbopol 974P NF empty gel, Groups II and III were treated topically with carbopol gel containing 2.5% and 5% of Vitex doniana extract. Group IV received Betadine® 10% as standard drug. The efficacy of treatment was evaluated by planimetry and histological analysis. We secondary used the gel containing Vitex doniana at 2.5% and the pure extract at 10 mg/ml on the model of ear edema induced by xylene. Skin toxicity test was performed with the gel containing Vitex doniana at 5% and the pure extract at 30 mg/ml. Vitex doniana at 5% and 2.5% provided better wound contraction (91.14% and 86.38%) at day 12 post-excision when compared to control (51.15%). The results of histological evaluation supported the outcome of excision wound model. Moreover Vitex doniana inhibited significantly edema induced by xylene when compared to control (p< 0.05). In skin toxicity test, no abnormal symptoms were developed over 14 day-time period. Vitex doniana inhibits the topical inflammation and accelerate cutaneous wound repair.

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Published

2012-05-21

How to Cite

Amegbor, kossi, Metowogo, K., Eklu-Gadegbeku, K., Agbonon, A., Aklikokou, K. A., Napo-koura, G., & Gbeassor, M. (2012). PRELIMINARY EVALUATION OF THE WOUND HEALING EFFECT OF VITEX DONIANA SWEET (VERBENACEAE) IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 9(4), 584–590. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1337

Issue

Section

Research Papers