HYPOGLYCAEMIC AND ANTIDIABETIC EFFECT OF ROOT EXTRACTS OF CEIBA PENTANDRA IN NORMAL AND DIABETIC RATS

Authors

  • Paul Désiré Dzeufiet Djomeni
  • Léonard Tédong
  • Emmanuel Acha Asongalem
  • T. Dimo
  • S. D. Sokeng
  • P. Kamtchouing

Keywords:

Ceiba pentandra, Plant extract, Diabetes mellitus, Hypoglycaemic

Abstract

The effect of the root bark extract of Ceiba pentandra (Linn) in normal and streptozotocin-induced diabetic rats was studied. Blood glucose levels were determined after oral administration of graded doses of C. pentandra (40, 75,150 and 300 mg/kg) in fasted normal and diabetic groups. In both groups, 40 and 75 mg/kg of the extract, significantly reduced blood glucose levels 8 h after administration, which was consistent and time-dependent. C. pentandra at the lower dose of 40mg/kg produced blood -glucose-lowering effect of 40.0% and 48.9%, in normal and diabetic rats respectively when compared with control rats. The higher doses of 150 and 300 mg/kg did not affect significantly the blood glucose levels. In multiple dose studies, the diabetic rats were treated orally by gavages, twice a day for 3 days. On day 3, C. pentandra (40 and 75mg/kg) significantly decreased blood and urine glucose levels as compared to initial values. The 14 h fasting blood glucose concentration was lowered by 59.8 % and 42.8% at the doses of 40 and 75 mg/kg and the corresponding urine glucose levels reductions were 95.7% and 63.6%, respectively. The results indicated that C. pentandra possessed hypoglycaemic effect. The plant extract was capable of ameliorating at lower doses, hyperglycaemia in streptozotocin-induced diabetic rats and could be a potential source for isolation of new orally active agent(s) for anti-diabetic therapy.

Author Biographies

Paul Désiré Dzeufiet Djomeni

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon

Léonard Tédong

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon

Emmanuel Acha Asongalem

Department of Physiological Sciences, Faculty of Medicine and Biomedical Sciences, Pharmacology and Toxicology Unit, University of Yaounde I P.O Box 812 Yaoundé Cameroon,

T. Dimo

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon

S. D. Sokeng

Department of Biological Sciences, Faculty of Sciences, University of Ngaoundere, P.O Box 454 Ngaoundere Cameroon

P. Kamtchouing

Department of Animal Physiology, Faculty of Science , University of Yaounde I P.O Box 812 Yaounde Cameroon

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Published

2006-01-12

How to Cite

Djomeni, P. D. D., Tédong, L., Asongalem, E. A., Dimo, T., Sokeng, S. D., & Kamtchouing, P. (2006). HYPOGLYCAEMIC AND ANTIDIABETIC EFFECT OF ROOT EXTRACTS OF CEIBA PENTANDRA IN NORMAL AND DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 3(1), 129–136. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/14

Issue

Section

Research Papers

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