IN VIVO ANTIMALARIAL AND CYTOTOXIC PROPERTIES OF ANNONA SENEGALENSIS EXTRACT

Authors

  • Edith Ajaiyeoba
  • M. Falade
  • O. Ogbole
  • L. Okpako
  • Dora Akinboye

Keywords:

Annona senegalensis, Mice Antimalarial, Cytotoxicity, Plasmodium berghei

Abstract

The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona senegalensis Pers. (Annonaceae) was investigated in this study. The in vivo antimalarial activity of the methanol extract against Plasmodium berghei was assessed using the 4-day suppressive test procedure. The extract of A. senegalensis had intrinsic antimalarial property that were dose – dependent. At doses of 100mg/kg weight of mice, it produced significant chemosuppression of parasitemia (> 57%) when administered orally. It had the highest activity at 800mg/kg weight of mice (91.1%) compared to Chloroquine disphosphate, the standard reference drug which had a chemosuppression of 96.2%. The in vitro cytotoxicity evaluations were perfomed using A2780 ovarian cancer cells in the drug sensitivity assay. Extract of A. senegalensis exhibited low cytotoxicity with an IC50 of 28.8μg/ml. Preliminary phytochemical screening of the plant extract indicated the presence of alkaloids, saponins, tannins and cardiac glycosides. This finding supports the traditional use of the plant for the treatment of malaria.

Author Biographies

Edith Ajaiyeoba

Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Nigeria.

M. Falade

Department of Zoology, Faculty of Science, University of Ibadan, Nigeria

O. Ogbole

Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University Sagamu, Nigeria.

L. Okpako

National Institute for Pharmaceutical Research & Development, P.M.B. 21, Garki, Abuja,

Dora Akinboye

Department of Zoology, Faculty of Science, University of Ibadan, Nigeria

Downloads

Published

2006-01-12

How to Cite

Ajaiyeoba, E., Falade, M., Ogbole, O., Okpako, L., & Akinboye, D. (2006). IN VIVO ANTIMALARIAL AND CYTOTOXIC PROPERTIES OF ANNONA SENEGALENSIS EXTRACT. African Journal of Traditional, Complementary and Alternative Medicines, 3(1), 137–141. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/15

Issue

Section

Research Papers

Most read articles by the same author(s)