STUDY ON ANTI-TUMOR EFFECT OF TOTAL GLYCOSIDES FROM RADIX PAEONIAE RUBRA IN S180 TUMOR-BEARING MICE

Authors

  • Wanpeng Xu
  • Wei Zhong
  • Jinlan Liu
  • Hong Liu
  • Bing Zhu

Keywords:

total glycosides of Radix Paeoniae Rubra, S180 sarcoma, IL-2, IL-4

Abstract

The objective of the paper was to study the anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice, and to preliminarily explore its mechanism of action. Mice were made into S180 solid tumor model, grouped and administered with the extracts; tumor inhibition rate was measured by harvesting the tumors, and serum IL-2 and IL-4 levels were measured by taking blood samples. Total glycosides of Radix paeoniae rubra significantly inhibited the growth of tumor cells in tumor-bearing organisms, enhanced the cytotoxic activity of NK cells, and increased the serum IL-2 and IL-4 levels. Total glycosides of Radix paeoniae rubra have some anti-tumor effect in vivo, which might have been accomplished through the regulation of the immune system.

Author Biography

Wanpeng Xu

Department of Colon &Anorectal Surgery, Affiliated Hospital of Weifang Medical University, Weifang, 261031, China

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Published

2013-03-19

How to Cite

Xu, W., Zhong, W., Liu, J., Liu, H., & Zhu, B. (2013). STUDY ON ANTI-TUMOR EFFECT OF TOTAL GLYCOSIDES FROM RADIX PAEONIAE RUBRA IN S180 TUMOR-BEARING MICE. African Journal of Traditional, Complementary and Alternative Medicines, 10(3), 580–585. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1810

Issue

Vol. 10 No. 3 (2013)

Section

Research Papers

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