STUDY ON THE EFFECT OF POLYSACCHARIDES FROM SOLANUM NIGRUM LINNE ON CELLULAR IMMUNE FUNCTION IN TUMOUR-BEARING MICE

Authors

  • Hai Chen
  • Xiaodong Qi

Keywords:

Solanum nigrum polysaccharides, tumour-bearing mice, cellular immunity

Abstract

We investigated the anti-tumour effect of polysaccharides from Solanum nigrum Linne, and its relationship with the immune function of tumour-bearing organisms, MTT assay was used to observe the effect of different doses of polysaccharides from Solanum nigrum Linne on proliferation of lymphocytes in tumour-bearing mice. ELISA assay was also used to detect the levels of IL-2 in mice, and a laser scanning confocal microscope was used to detect the effect of polysaccharides from Solanum nigrum Linne on intralymphocytic free calcium ion concentration in tumour-bearing mice. Different doses of polysaccharides from Solanum nigrum Linne significantly inhibited the growth of mouse H22 solid tumours, improved the survival time of tumour-bearing mice, increased the proliferation of lymphocytes, elevated the levels of IL-2, and increased the concentration of calcium ions in the lymphocytes. Polysaccharides from Solanum nigrum Linne have certain anti-tumour effect, which is related with the cellular immune function that regulates the body.

Author Biography

Hai Chen

Department of Galactophore, The Military General Hospital of Beijing PLA, Beijing, China

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Published

2013-04-19

How to Cite

Chen, H., & Qi, X. (2013). STUDY ON THE EFFECT OF POLYSACCHARIDES FROM SOLANUM NIGRUM LINNE ON CELLULAR IMMUNE FUNCTION IN TUMOUR-BEARING MICE. African Journal of Traditional, Complementary and Alternative Medicines, 10(4), 41–46. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1834

Issue

Vol. 10 No. 4 (2013)

Section

Research Papers

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