HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS

Authors

  • saleh Mohammed Rahim Dept of Biology ,Faculty of Education, University of Tikrit, IRAQ
  • Ekhlass Muhi Taha
  • Muneef Saeb Al-janabi
  • Bushra Ismael Al-douri
  • Kumar Das Simon
  • Abd Gaffar Mazlan

Keywords:

Traditional Medicines, Alternative Medicines

Abstract

Background: Cymbopogon citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against liver injury induced by hydrogen peroxide (H2O2), in male rats. Materials and Methods: Twenty-five rats were randomly divided into five different groups of five animals in each group viz; (1) Control. (2) Received H2O2 (0.5%) with drinking water. (3), and (4) received H2O2 and C. citratus (100 mg•kg-1 b wt), vitamin C (250 mg•kg-1 b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total bilirubin and malonaldehyde, glutathione in serum and liver homogenates. Liver was excised and routinely processed for histological examinations. Results: C. citratus attenuated liver damage due to H2O2 administration as indicated by the significant reduction (p<0.05), in the elevated levels of ALT, AST, ALP, LDH, TB, and MDA in serum and liver homogenates; increase in TP and GSH levels in serum and liver homogenates; and improvement of liver histo-pathological changes. These effects of the extract were similar to that of vitamin C which used as antioxidant reference.

Author Biography

saleh Mohammed Rahim, Dept of Biology ,Faculty of Education, University of Tikrit, IRAQ

Biology

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Published

2014-01-23

How to Cite

Rahim, saleh M., Taha, E. M., Al-janabi, M. S., Al-douri, B. I., Das Simon, K., & Mazlan, A. G. (2014). HEPATOPROTECTIVE EFFECT OF CYMBOPOGON CITRATUS AQUEOUS EXTRACT AGAINST HYDROGEN PEROXIDE-INDUCED LIVER INJURY IN MALE RATS. African Journal of Traditional, Complementary and Alternative Medicines, 11(2), 447–451. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1877

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Section

Research Papers