SYNERGISTIC ANTIMICROBIAL ACTIVITIES OF PHYTOESTROGENS IN CRUDE EXTRACTS OF TWO SESAME SPECIES AGAINST SOME COMMON PATHOGENIC MICROORGANISMS.

Authors

  • M. A. Bankole Dept. of Anatomy, College of Medicine, Lagos State University PMB 21266 Ikeja Lagos, Nigeria
  • Lukeman J. A. Shittu
  • T. A. Ahmed
  • M. N. Bankole
  • R. K. Shittu
  • T. Kpela
  • O. A. Ashiru

Keywords:

Pathogenic micro-organisms, Gram-positive, Gram-negative, Yeast, Anti-microbial, Sesame leaves, GC-MS, MIC..

Abstract

Intensive studies on extracts and biologically active compounds isolated from medicinal plants have doubled in the last decade worldwide. However, as a result of paucity of knowledge and folkloric claim on the effectiveness of sesame leaves in infectious disease treatments, we aimed to determine the synergistic antimicrobial activity of essential oils and lignans present in the crude leaves extracts of Sesame radiatum and Sesame indicum. Ethanolic, methanolic and aqueous extracts of both leaves were studied for their in-vitro synergistic antimicrobial activity against both Gram positive and Gram negative micro-organisms, and Yeast using Agar diffusion method. The GC-MS phytochemical screening of methanolic extract showed that the major compounds in essential oils are of carboxylic acids and phenolic groups especially, the most potent antioxidants known to man like sesamol, sesamolin and sesamin among others. Methanolic and ethanolic extracts have broad spectrum antimicrobial effect against all the tested pathogenic micro-organisms except Streptococcus pneumoniae and Staphylococcus aureus respectively, while the aqueous extract exhibited inhibitory activity on Staphylococcus aureus, Streptococcus pneumoniae and Candida albicans. The result confirmed the folkloric claims of the antimicrobial effectiveness of locally consumed sesame leaves extracts especially against bacterial and common skin infection in many areas of Nigeria .

Author Biographies

M. A. Bankole, Dept. of Anatomy, College of Medicine, Lagos State University PMB 21266 Ikeja Lagos, Nigeria

Department of Medical Microbiology and Parasitology, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Idi-araba, Lagos, Nigeria

Lukeman J. A. Shittu

Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria

T. A. Ahmed

Department of Microbiology, Drug Quality Control Laboratory/Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria.

M. N. Bankole

Diarrhea Unit, Microbiology Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria

R. K. Shittu

Medical Microbiology Unit, Bolomedics Laboratories, Egbeda, Lagos, Nigeria.

T. Kpela

Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.

O. A. Ashiru

Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria.

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Published

2007-06-10

How to Cite

Bankole, M. A., Shittu, L. J. A., Ahmed, T. A., Bankole, M. N., Shittu, R. K., Kpela, T., & Ashiru, O. A. (2007). SYNERGISTIC ANTIMICROBIAL ACTIVITIES OF PHYTOESTROGENS IN CRUDE EXTRACTS OF TWO SESAME SPECIES AGAINST SOME COMMON PATHOGENIC MICROORGANISMS. African Journal of Traditional, Complementary and Alternative Medicines, 4(4), 427 –. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/203

Issue

Section

Research Papers