IN VIVO SCREENING OF ANTIMALARIAL ACTIVITY OF ACACIA MELLIFERA (BENTH) (LEGUMINOSAE) ON PLASMODIUM BERGHEI IN MICE

Authors

  • Charles Mutai Kenya Medical Research Institute
  • Geoffrey Rukunga Kenya Medical Research Institute
  • Vassilios Roussis University of Athens
  • Vagias Constatinos University of Athens

Keywords:

Acacia mellifera, lupane triterpenes, Antimalarial activity, mice

Abstract

The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.

Author Biographies

Charles Mutai, Kenya Medical Research Institute

Center for Traditional Medicine and Drug Research, Senior Research Scientist

Geoffrey Rukunga, Kenya Medical Research Institute

Center for Traditional Medicine and Drug Research, Chief Research Scientist

Vassilios Roussis, University of Athens

Department of pharmacy, Division of Phamacognosy and Chemistry of Natural Products. Professor

Vagias Constatinos, University of Athens

Department of pharmacy, Division of phamacognosy and Chemistry of Natural Products. Professor

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Published

2007-09-04

How to Cite

Mutai, C., Rukunga, G., Roussis, V., & Constatinos, V. (2007). IN VIVO SCREENING OF ANTIMALARIAL ACTIVITY OF ACACIA MELLIFERA (BENTH) (LEGUMINOSAE) ON PLASMODIUM BERGHEI IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 5(1), 46–50. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/207

Issue

Vol. 5 No. 1 (2008)

Section

Research Papers

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