APOPTOSIS INDUCING EFFECT OF ANDROGRAPHOLIDE ON TD-47 HUMAN BREAST CANCER CELL LINE

Authors

  • Sukardiman Harjotaruno
  • Aty Widyawaruyanti
  • - Sismindari
  • N. C. Zaini

Keywords:

Andrographis paniculata Ness, andrographolide, TD-47 cell, apoptosis

Abstract

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM , 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24 , 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax , caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis

Author Biographies

Sukardiman Harjotaruno

Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University Surabaya Indonesia

Aty Widyawaruyanti

Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University Surabaya Indonesia

- Sismindari

Department Pharmaceutical Chemistry Faculty of Pharmacy Gadjah Mada University Yogyakarta, Indonesia

N. C. Zaini

Department of Natural Product Sciences, Faculty of Pharmacy Airlangga University Surabaya Indonesia

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Published

2007-02-16

How to Cite

Harjotaruno, S., Widyawaruyanti, A., Sismindari, .-., & Zaini, N. C. (2007). APOPTOSIS INDUCING EFFECT OF ANDROGRAPHOLIDE ON TD-47 HUMAN BREAST CANCER CELL LINE. African Journal of Traditional, Complementary and Alternative Medicines, 4(3), 345–351. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/227

Issue

Vol. 4 No. 3 (2007)

Section

Research Papers

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