ANTIOXIDANT ACTIVITIES AND TYROSINASE INHIBITION EFFECTS OF PHALERIA MACROCARPA EXTRACTS.

Authors

  • Muhammad Helmi Nadri Department of Biosciences and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia
  • Yushatika Salim Department of Biosciences and Health Sciences Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia
  • Norazah Basar Department of Biosciences and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia
  • Azli Yahya Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia
  • Razauden Mohamed Zulkifli

Keywords:

Phaleria macrocarpa, Antioxidant, Total phenolic content, Tyrosinase inhibition

Abstract

Background: The ethyl acetate and chloroform extracts of stems, leaves and fruits of Phaleria macrocarpa were screened for their antioxidant capacity and tyrosinase inhibition properties. Material and Method: The total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and ferric-ion reducing power (FRAP) were used to evaluate their antioxidant capacity. Tyrosinase inhibition effect was measured using mushroom tyrosinase inhibition assay. Result: Ethyl acetate extract of P. macrocarpa’s stem exhibited highest total phenolic content, DPPH free radical scavenging and ferric reducing power. Meanwhile, chloroform extracts of leaves and fruits demonstrated potent anti-tyrosinase activities as compared to a well-known tyrosinase inhibitor, kojic acid. Conclusion: Since chloroform extracts of leaves and fruits have low antioxidant capacities, the tyrosinase inhibition effect observed are antioxidant independent. This study suggests direct tyrosinase inhibition by chloroform extracts of Phaleria macrocarpa.

Author Biographies

Muhammad Helmi Nadri, Department of Biosciences and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia

Department of Biosciences and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia

Yushatika Salim, Department of Biosciences and Health Sciences Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia

Undergraduate Student Department of Biosciences and Health Sciences Faculty of Biosciences and Medical Engineering

Norazah Basar, Department of Biosciences and Health Sciences, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia

Postgraduate Student Department of Biosciences and Health Sciences Faculty of Biosciences and Medical Engineering

Azli Yahya, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia (UTM), 81310 Skudai, Johor, Malaysia

Senior Lecturer Department of Chemistry, Faculty of Science

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Published

2014-03-29

How to Cite

Nadri, M. H., Salim, Y., Basar, N., Yahya, A., & Zulkifli, R. M. (2014). ANTIOXIDANT ACTIVITIES AND TYROSINASE INHIBITION EFFECTS OF PHALERIA MACROCARPA EXTRACTS. African Journal of Traditional, Complementary and Alternative Medicines, 11(3), 107–111. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/2279

Issue

Vol. 11 No. 3 (2014)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

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