EFFECT OF EUPHORBIA CYPARISSIAS OINTMENTS ON ACANTHOSIS

Authors

  • Romeo Teodor Cristina Banat's University of Agriculture and Veterinary Medicine, Timisoara
  • Eugenia Dumitrescu Faculty of Veterinary Medicine Timisoara, Romania, Veterinary Pharmacology & Pharmacy Dept
  • Diana Brezovan Faculty of Veterinary Medicine, TimiÈ™oara, Romania, Histology and Molecular biology Dept.
  • Florin Muselin Faculty of Veterinary Medicine, Department of Botany, Timisoara, Romania.
  • Viorica Chiurciu Drugs Production Dept., Romvac Company, Romania

Keywords:

acanthosis, Euphorbia cyparissias, ointments, rat, dog, dermatology test

Abstract

Background: A pharmaco-chemical investigation of the Euphorbia cyparissias plant was justified by its known multiple therapeutic valences. Numerous components from extracts and latex of Euphorbiacae were identified, revealing a large plant family with a polyvalent therapeutic activity. Materials and Methods: The aim of the study was to assess the skin tolerance level to irritation on different testing concentrations, of Euphorbia cyparissias extracts and ointments. Study was accomplished in rats and dogs, with the identification of all possible skin injuries and histological changes, after a simple patch test methodology. Results: Ointment dermatological testing on rats, proved to be bearable on epilated skin at concentrations of 1, 2 and 5%. Ointments and mother tincture with higher concentrations (10% and 20%), led to irritation and cutis damages, and this was revealed through histology. Conclusion: Ointment tested on dog’s skin was tolerable for epilated skin to concentrations of 1, 2 and/or 5%, additional testing on human volunteers confirmed the same situation.

Author Biographies

Romeo Teodor Cristina, Banat's University of Agriculture and Veterinary Medicine, Timisoara

Head of Veterinary Pharmacology & Pharmacy to Faculty of Veterinary Medicine

Eugenia Dumitrescu, Faculty of Veterinary Medicine Timisoara, Romania, Veterinary Pharmacology & Pharmacy Dept

PhD., Lecturer

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Published

2014-03-27

How to Cite

Cristina, R. T., Dumitrescu, E., Brezovan, D., Muselin, F., & Chiurciu, V. (2014). EFFECT OF EUPHORBIA CYPARISSIAS OINTMENTS ON ACANTHOSIS. African Journal of Traditional, Complementary and Alternative Medicines, 11(3), 1–6. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/2281

Issue

Vol. 11 No. 3 (2014)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

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