FLAVONOIDS, ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF MACFADYENA UNGUIS-CATI L.

Authors

  • E. A. Aboutabl National Research Centre
  • Fatma A. Hashem
  • A. A. Sleem
  • A. A. Maamoon

Keywords:

, Macfadyena unguis-cati L., Bignoniaceae, flavonoids, anti-inflammatory, cytotoxicity.

Abstract

Ethyl acetate and ethanol extracts of unflowering aerial part of Macfadyena unguis-cati L.(Fam. Bignoniaceae) were found to be rich in phenolic compounds. From ethyl acetate extract,six flavonoids were identified, 8, methoxy, acacetin, 7-O glucoside; 6, methoxy apigenin 7-O glucoside; 4`-O methyl scutellarin, 6-O apiosyl galactoside; acacetin, 7-O glucosyl, 8-C rhamnosyl, 3-O- arabinofuranoside; 4`-methyl, 6- methoxy kaempferol, 7-O, 8-C diglucoside and vicenin II were isolated, while 6, methoxy, acacetin 7-O glucoside; and quercitrin were isolated from ethanol extract. These compounds were characterized and identified by their physicochemical and spectral data. The crude ethanol extract exhibited significant anti-inflammatory activity (80.47%) and moderate cytotoxic activity against lung cell line.

Author Biographies

E. A. Aboutabl, National Research Centre

Pharmacognosy Department., Faculty of Pharmacy, Cairo University.

Fatma A. Hashem

Pharmacognosy Department., National Research Centre, Tahrir Street, Dokki, Cairo, Egypt

A. A. Sleem

Pharmacology Department., National Research Centre, Tahrir Street, Dokki, Cairo, Egypt.

A. A. Maamoon

Pharmacognosy Department., National Research Centre, Tahrir Street, Dokki, Cairo, Egypt

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Published

2007-09-04

How to Cite

Aboutabl, E. A., Hashem, F. A., Sleem, A. A., & Maamoon, A. A. (2007). FLAVONOIDS, ANTI-INFLAMMATORY ACTIVITY AND CYTOTOXICITY OF MACFADYENA UNGUIS-CATI L. African Journal of Traditional, Complementary and Alternative Medicines, 5(1), 18–26. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/234

Issue

Vol. 5 No. 1 (2008)

Section

Research Papers

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