ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF METHANOL EXTRACTS AND ALKALOID FRACTIONS OF FOUR MEXICAN MEDICINAL PLANTS OF SOLANACEAE

Authors

  • Dora Marina Gutiérrez-Avella Universidad Autónoma de Querétaro
  • Moustapha Bah
  • María L. Garduño R.
  • Sandra O. Mendoza D.
  • Valentina Serrano C.

Keywords:

Solanaceae family, antioxidant activity, anti-inflammatory activity

Abstract

Background: Methanol extracts and alkaloid fractions of different parts of four plant species belonging to Solanaceae family and used in Mexican traditional medicine were investigated for their total phenolic contents, anti-inflammatory and antioxidant properties. Materials and Methods: The total phenolic compounds of each extract was determined according to the Folin-Ciocalteu method, while the in vitro radical scavenging activities of the extracts were assessed using the DPPH and ABTS radicals. The in vivo anti-inflammatory activity was determined using the TPA-induced mouse ear edema model. Results: The methanol extracts contained the highest concentrations of phenolic compounds and also exhibited the best reducing power on the DPPH and ABTS radicals, in a concentration-dependent fashion. However, the anti-inflammatory activity did not follow the same trend, as some alkaloid fractions that showed low radical reducing power exhibited the strongest anti-inflammatory activity. Conclusion: The methanol extract obtained from the flowers of Nicotiana glauca presented the best overall performance with the largest amount of phenolic compounds (111 µg garlic acid equivalents/g of extract), the best antioxidant activity (94.80% inhibition of DPPH and 97.57% of ABTS) and the highest anti-inflammatory activity (81.93% inhibition of the inflammation

Author Biography

Dora Marina Gutiérrez-Avella, Universidad Autónoma de Querétaro

Department of Chemistry Researcher and Professor

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Published

2014-03-29

How to Cite

Gutiérrez-Avella, D. M., Bah, M., Garduño R., M. L., Mendoza D., S. O., & Serrano C., V. (2014). ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITIES OF METHANOL EXTRACTS AND ALKALOID FRACTIONS OF FOUR MEXICAN MEDICINAL PLANTS OF SOLANACEAE. African Journal of Traditional, Complementary and Alternative Medicines, 11(3), 259–267. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/2374

Issue

Section

Research Papers

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