ANTIGENOTOXIC EFFECT OF FERULIC ACID IN 7,12-DIMETHYL BENZ(A)-ANTHRACENE (DMBA) INDUCED GENOTOXICITY
Keywords:
DMBA, ferulic acid, genotoxicity, chromosomal aberrations,Abstract
The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30mg kg-1 b.w). Pretreatment of ferulic acid orally at a dose of 40mg kg-1 b.w for five days significantly reduced the frequency of micronucleated polychromatic erythrocytes (MnPCEs) and the percentage of chromosomal aberrations in hamster’s bone marrow. Our results thus suggest that ferulic acid has potent antigenotoxic effect in DMBA induced genotoxicity in golden Syrian hamsters.Downloads
Published
2007-09-04
How to Cite
Balakrishnan, S., Menon, V. P., Manoharan, S., & Rajalingam, K. (2007). ANTIGENOTOXIC EFFECT OF FERULIC ACID IN 7,12-DIMETHYL BENZ(A)-ANTHRACENE (DMBA) INDUCED GENOTOXICITY. African Journal of Traditional, Complementary and Alternative Medicines, 5(1), 32–38. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/242
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Section
Research Papers
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