ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE ACTIVITIES OF METHANOLIC EXTRACT OF THE LEAVES OF FRAXINUS FLORIBUNDA WALLICH

Authors

  • Sutharson Lingadurai
  • Lila Kanta Nath
  • Prasanna Kumar Kar
  • Shila E. Besra
  • Rajan Vedasiromani Joseph

Keywords:

Fraxinus floribunda, Carrageenan, Cotton pellet, Freund’s adjuvant, Writhing test, Tail immersion test.

Abstract

Fraxinus floribunda Wallich (Family-Oleaceae) is a wide green tree in the sub-alpine region of Sikkim, India. The methanolic extract of the leaves of Fraxinus floribunda (MEFF) at 100, 200 and 400mg/kg/p.o was screened in rats for anti-inflammatory activity by acute-carrageenan induced paw edema, sub-acute cotton pellet induced granuloma and chronic Freund’s adjuvant induced arthritis models. In all the three models of anti-inflammatory studies 200 and 400mg/kg/p.o doses of the extract showed significant effect (P<0.001). Anti-nociceptive evaluation was performed by writhing and tail-immersion tests in mice. Anti-nociceptive evaluation revealed that MEFF at the dose of 400mg/kg/p.o had significant activity against the control. The relieving effect was through the peripheral and central mechanism of action of the extract. This study rationalized the ethno medicinal use of the plant for relieving pain in inflammatory pathological conditions like fracture and dislocation.

Author Biographies

Sutharson Lingadurai

Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim-737136, India.

Lila Kanta Nath

Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim-737136, India.

Prasanna Kumar Kar

Department of Pharmacology, Himalayan Pharmacy Institute, Majhitar, Rangpo, Sikkim-737136, India.

Shila E. Besra

Drug Development Division, Indian Institute of Chemical Biology, Kolkata-700032, India.

Rajan Vedasiromani Joseph

Drug Development Division, Indian Institute of Chemical Biology, Kolkata-700032, India.

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Published

2007-06-10

How to Cite

Lingadurai, S., Nath, L. K., Kar, P. K., Besra, S. E., & Joseph, R. V. (2007). ANTI-INFLAMMATORY AND ANTI-NOCICEPTIVE ACTIVITIES OF METHANOLIC EXTRACT OF THE LEAVES OF FRAXINUS FLORIBUNDA WALLICH. African Journal of Traditional, Complementary and Alternative Medicines, 4(4), 411 –. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/268

Issue

Section

Research Papers