IN VITRO ANTIOXIDANT ACTIVITIES OF THE FRACTIONS OF COCCINIA GRANDIS L. LEAF EXTRACT

Authors

  • M. Umamaheswari
  • T. K. Chatterjee

Keywords:

Coccinia grandis (Cucurbitaceae), free radicals, antioxidant, pro-oxidant.

Abstract

The present study was aimed at investigating the antioxidant activities of the various fractions of the hydromethanolic extract of the leaves of Coccinia grandis L. Voigt. (Cucurbitaceae). The antioxidant activities of the fractions have been evaluated by using nine in vitro assays and were compared to standard antioxidants such as ascorbic acid, α-tocopherol, curcumin and butylated hydroxyl toluene (BHT). All the fractions showed effective H-donor activity, reducing power, free radical scavenging activity, metal chelating ability and inhibition of β-carotene bleaching. None of the fractions exerted an obvious pro-oxidant activity. The antioxidant property depends upon concentration and increased with increasing amount of the fractions. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds present in the fractions. The results obtained in the present study indicate that the leaves of C. grandis are a potential source of natural antioxidant.

Author Biographies

M. Umamaheswari

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

T. K. Chatterjee

Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.

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Published

2007-09-04

How to Cite

Umamaheswari, M., & Chatterjee, T. K. (2007). IN VITRO ANTIOXIDANT ACTIVITIES OF THE FRACTIONS OF COCCINIA GRANDIS L. LEAF EXTRACT. African Journal of Traditional, Complementary and Alternative Medicines, 5(1), 61–73. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/326

Issue

Vol. 5 No. 1 (2008)

Section

Research Papers

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