EFFECTS OF THE HEXANE EXTRACT OF MONDIA WHITEI ON THE REPRODUCTIVE ORGANS OF MALE RAT.

Authors

  • Pierre Watcho
  • Mireille M. Donfack
  • Fabien Zelefack
  • Telesphore B. Nguelefack
  • Sylvie Wansi
  • Ferdinand Nguola
  • Pierre Kamtchouing
  • Etienne Tsamo
  • Albert Kamanyi

Keywords:

Mondia whitei, ethnomedical, cholesterol, aphrodisiac, accessory reproductive organs

Abstract

The present study investigates the effects induced by the long term oral administration of the hexane extract of the dried roots of Mondia whitei at doses of 500 and 1000 mg/kg b.w. on body and organ weights, biochemical (cholesterol, total proteins), haematological (WBC, RBC, haematocrit) and physiological (mechanical response of vas deferens to Norepinephrine) parameters of rats treated for 30 days. Results showed that Mondia whitei did not affect the body and testes weights of rats. At high dose (1000 mg/kg b.w), there was a significant (p<0.05) increase of the relative weights of the caput epididymis, ventral prostate and seminal vesicle whereas at low dose (500 mg/kg b.w), there were growth of the ventral prostate and decrease in the relative weight of the proximal vas deferens as compared with control rats. At all doses, intratesticular cholesterol was decreased, serum and tissue total protein contents increased whilst the haematological variables were within the normal range. Norepinephrine (0.114-3.648 µM) produced concentration-dependent contraction of the vas deferens of rats treated with 500 mg/kg b.w and 1000 mg/kg b.w for 30 days. In rats allowed a washout period of 30 days, except the relative proximal vas deferens where a significant decrease (P < 0.001) was noticed, no change was recorded. These findings give evidence of the reversible androgenic effect of Mondia whitei and partially support its folk use as aphrodisiac.

Author Biographies

Pierre Watcho

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon

Mireille M. Donfack

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon

Fabien Zelefack

Department of Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon,

Telesphore B. Nguelefack

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon

Sylvie Wansi

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon

Ferdinand Nguola

Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon.

Pierre Kamtchouing

Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon.

Etienne Tsamo

Department of Chemistry, Faculty of Science, University of Yaounde I, Box 812 Yaounde, Cameroon

Albert Kamanyi

Animal Physiology and Phytopharmacology Laboratory, Faculty of Science, University of Dschang, Box 67 Dschang, Cameroon,

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Published

2006-01-07

How to Cite

Watcho, P., Donfack, M. M., Zelefack, F., Nguelefack, T. B., Wansi, S., Nguola, F., Kamtchouing, P., Tsamo, E., & Kamanyi, A. (2006). EFFECTS OF THE HEXANE EXTRACT OF MONDIA WHITEI ON THE REPRODUCTIVE ORGANS OF MALE RAT. African Journal of Traditional, Complementary and Alternative Medicines, 2(3), 302 –. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/34

Issue

Section

Research Papers

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