BIOLOGICAL ACTIVITIES OF ASPARAGUS RACEMOSUS

Authors

  • Buppachart Potduang
  • Maneerat Meeploy
  • Rattanasiri Giwanon
  • Yaowaluck Benmart
  • Montree Kaewduang
  • Winai Supatanakul

Keywords:

Asparagus racemosus, Antioxidant, Antityrosinase, Antimicrobial, Phytochemistry

Abstract

Cytotoxic, antioxidant, tyrosinase inhibitory, antimicrobial activities of the crude ethanol extract of dry powdered roots of Asparagus racemosus (Liliaceae) were investigated. The LC50 to brine shrimp was 2189.49 μg/ml; the EC50 for DPPH radical scavenging was 381.91 μg/ml; the IC50 for tyrosinase inhibition was 7.98 mg/ml. The extract was active at 5-20 mg/ml against various pathogenic microbial (16 species, 18 strains) using the agar dilution assay, with the minimum inhibitory concentration (MIC) between 10-20 mg/ml for enteropathogens, the MIC between 5-20 mg/ml for dermatopathogens, and MIC = 10 mg/ml for a pneumonia causing bacteria Klebsiella pneumoniae. TLC and HPLC finger printing showed the presence of steroidsterpenes, alkaloids and flavonoids

Author Biographies

Buppachart Potduang

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

Maneerat Meeploy

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

Rattanasiri Giwanon

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

Yaowaluck Benmart

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

Montree Kaewduang

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

Winai Supatanakul

Pharmaceuticals and Natural Products Department Thailand Institute of Scientific and Technological Research, Technopolis, Thanon Liab Klong 5, Klong Luang, Pathumthani 12120, Thailand.

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Published

2008-04-08

How to Cite

Potduang, B., Meeploy, M., Giwanon, R., Benmart, Y., Kaewduang, M., & Supatanakul, W. (2008). BIOLOGICAL ACTIVITIES OF ASPARAGUS RACEMOSUS. African Journal of Traditional, Complementary and Alternative Medicines, 5(3), 230–237. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/417

Issue

Section

Research Papers