NEUROPROTECTIVE EFFECT OF TERMINALIA CHEBULA EXTRACTS AND ELLAGIC ACID IN PC12 CELLS

Authors

  • Yuh-Chiang Shen National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C).
  • Chi-Wen Juan Juan National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C).
  • Chi-Wen Juan Juan National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C).
  • Che-San Lin Department of Critical Care Medicine, Kuang Tien General Hospital, Taichung city, Taiwan (R.O.C)
  • Che-San Lin
  • Chien-Chih Chen
  • Chien-Chih Chen
  • Chia-Lin Chang
  • Chia-Lin Chang

DOI:

https://doi.org/10.21010/ajtcam.v14i4.3

Keywords:

Tradtional Medicine

Abstract

Alzheimer’s disease (AD) is one of the most prevalent severe neurological disorders afflicting our aged population. The study was to determine neuroprotective effects of the Terminalia chebula extracts and ellagic acid by using beta-amyloid25-35 (Ab25-35)-induced cell cytotoxicity in undifferentiated rat pheochromocytoma (PC12) cellular model. The methanolic and water extracts of T. chebula and ellagic acid exhibited the strongest neuroprotective activity against Ab25-35-induced undifferentiated PC12 cell deaths at 0.5–5.0 ug/ml. The ellagic acid also exhibited the partial neuroprotective activity against H2O2-induced undifferentiated PC12 cell deaths at 0.5–5.0 ug/ml. The methanolic and water extracts of T. chebula and ellagic acid protected undifferentiated PC12 cells from the damaging effects of Ab25-35 in several ways: (1) by securing cell viability; (2) by suppressing reactive oxygen species production; and (3) by eliminating calcium ion influx. The T. chebula extracts maybe represent a promising plant-source for medicine in the application of the treatment of AD. Further investigation of the ellagic acid is necessary to verify the neuroprotective efficacy and mechanisms in vivo.

Downloads

Published

2017-06-05

How to Cite

Shen, Y.-C., Juan, C.-W. J., Juan, C.-W. J., Lin, C.-S., Lin, C.-S., Chen, C.-C., Chen, C.-C., Chang, C.-L., & Chang, C.-L. (2017). NEUROPROTECTIVE EFFECT OF TERMINALIA CHEBULA EXTRACTS AND ELLAGIC ACID IN PC12 CELLS. African Journal of Traditional, Complementary and Alternative Medicines, 14(4), 22–30. https://doi.org/10.21010/ajtcam.v14i4.3

Issue

Vol. 14 No. 4 (2017)

Section

Research Papers

License

Copyright: Creative Commons Attribution CC.

This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials. View License Deed | View Legal Code Authors can also self-archive their manuscripts immediately and enable public access from their institution's repository. This is the version that has been accepted for publication and which typically includes author-incorporated changes suggested during submission, peer review and in editor-author communications.