MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS

Authors

  • Yanrong Chen
  • Yanke Li
  • Huali Xu
  • Gang Li
  • Yunxia Ma
  • Yu Jun Pang

DOI:

https://doi.org/10.21010/ajtcam.v14i2.36

Keywords:

Focal cerebral ischemia, oxidative stress, apoptosis, inflammation, lipid peroxidation, morin

Abstract

Background: Morin is a flavanoid which exhibits potent antioxidant activity in various oxidative stress related diseases. The current study was attempted to scrutinize the preclinical bio-efficacy of morin on focal ischemia. Methods: The animal model of focal cerebral ischemic injury was done by midbrain carotid artery occlusion (MCAO) method, followed by Morin (30mg/kg) administration for seven days. Results: The outcome of the study showed that treatment with morin displayed positive effects in reducing the focal cerebral ischemia. This effect was evident with the improvements in neurological deficits, reduction in MDA content and elevation of antioxidant levels (SOD, GSH and Gpx). Furthermore, protein expression of Bax and caspase-3 were effectively down-regulated, whilst the expression of Bcl-2 was significantly elevated. On the other hand, the mRNA expression of proinflammatory cytokines was significantly reduced in focal cerebral ischemic rats upon morin intervention. Conclusion: Thus, the beneficial effects of morin on cerebral ischemia assault may result from the reduction of oxidative stress, inhibition of apoptosis and inflammation.

Author Biography

Yanrong Chen

Drug Research & Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria

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Published

2017-01-13

How to Cite

Chen, Y., Li, Y., Xu, H., Li, G., Ma, Y., & Pang, Y. J. (2017). MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 14(2), 348–355. https://doi.org/10.21010/ajtcam.v14i2.36

Issue

Vol. 14 No. 2 (2017)

Section

Research Papers

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