ANTI-INFLAMMATORY, ANTI-NOCICEPTIVE AND ANTIPYRETIC POTENTIAL OF TERMINALIA CITRINA FRUIT EXTRACTS

Authors

  • Ammara Saleem
  • Aqeel Javeed
  • Muhammad Ashraf
  • Muhammad Furqan Akhtar
  • Bushra Akhtar
  • Ali Sharif
  • Kanwal Akhtar
  • Moosa Raza
  • Irfan Hamid
  • Sohaib Peerzada
  • Shoaib Ahmad
  • Sania Atta

DOI:

https://doi.org/10.21010/ajtcam.v14i5.4

Keywords:

Ethnopharmacology, anti-inflammatory, writhing, pyrexia, pain, Brewer’s yeast

Abstract

Background: Plants and herbs have long been used as remedies without scientific evidences. The objective of the present study was to explore the anti-inflammatory, anti-nociceptive and antipyretic potential of ethanolic and aqueous extracts of Terminalia citrina fruits in mice. Materials and Methods: Extracts of Terminalia citrina fruits were evaluated at doses of 200mg/kg, 400mg/kg and 600mg/kg in albino mice for preventive effect in inflammatory edema, peripheral pain sensation and pyrexia. Carrageenan induced paw edema method was utilized to evaluate anti-inflammatory activity. Analgesic appraisal of extracts was demonstrated using acetic acid induced writhing model of pain. Antipyretic potential was determined by brewer’s yeast induced pyrexia model. Statistical analysis was conducted by ANOVA following post hoc test. Results: Both extracts exhibited significant and dose-dependent anti-inflammatory, analgesic and antipyretic activities. The ethanolic extract was more effective in reducing inflammatory edema, pyrexia and pain sensation than aqueous extracts in all tested doses. Conclusion: It can be concluded that fruit extracts of Terminalia citrina may be effective in reducing inflammation, pyrexia and pain sensation in animals.

Author Biographies

Ammara Saleem

Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.

Aqeel Javeed

Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.

Muhammad Ashraf

Department of Pharmacology and Toxicology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Muhammad Furqan Akhtar

Faculty of Pharmaceutical Sciences, GC University, Faisalabad, Pakistan.

Bushra Akhtar

Institute of Pharmacy, Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.

Ali Sharif

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.

Kanwal Akhtar

Centre of Excellence in Solid State Physics, University of the Punjab, Pakistan

Moosa Raza

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.

Irfan Hamid

Mirpur University of Science and Technology, AJK, Pakistan.

Sohaib Peerzada

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan

Sania Atta

Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan

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Published

2017-10-01

How to Cite

Saleem, A., Javeed, A., Ashraf, M., Akhtar, M. F., Akhtar, B., Sharif, A., Akhtar, K., Raza, M., Hamid, I., Peerzada, S., Ahmad, S., & Atta, S. (2017). ANTI-INFLAMMATORY, ANTI-NOCICEPTIVE AND ANTIPYRETIC POTENTIAL OF TERMINALIA CITRINA FRUIT EXTRACTS. African Journal of Traditional, Complementary and Alternative Medicines, 14(5), 24–30. https://doi.org/10.21010/ajtcam.v14i5.4

Issue

Vol. 14 No. 5 (2017)

Section

Research Papers

License

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