EFFECTS OF GLYCYRRHIZIN PRE-TREATMENT ON TRANSIENT ISCHEMIC BRAIN INJURY IN MICE

Authors

  • Chiyeon Lim
  • Sehyun Lim
  • Young-Jun Lee
  • Bokcheul Kong
  • Byoungho Lee
  • Chang- Hyun Kim
  • Buyeo Kim
  • Suin Cho

DOI:

https://doi.org/10.21010/ajtcam.v14i5.15

Keywords:

Glycyrrhizin, licorice, stroke, apoptosis

Abstract

Background: Ischemia-induced brain damage is the leading cause of adult disability and the fifth leading cause of death, and thus, the development of anti-apoptotic neuro-protective therapeutic agents is viewed as an attractive developmental strategy. Glycyrrhizin is the main sweet component in licorice and has a number of pharmacological activities, which include neuro-protective, anti-fungal, and anti-cariogenic activities. This study was undertaken to investigate the effects of glycyrrhizin on ischemia-induced brain damage. Materials and Methods: In infarct volumes and the levels of several apoptosis-related proteins, caspase-3, - 8, 9, Bcl-xL, Bcl-2,and their activities in the brains of middle cerebral artery occlusion (MCAO) treated mice were measured using western blotting methods. Results: Single pre-treatment with glycyrrhizin (10-100 mg/kg)at 2 hours before MCAO significantly reduced infarct volumes at 24h after MCAO. In addition, glycyrrhizin effectively inhibited the activations of caspase-3 and -9 and the down-regulation of Bcl-xLprotein caused by MCAO. Conclusion: The neuro-protective effect of glycyrrhizin was found to be due to its regulation of apoptosisrelated proteins signals.The authors suggest glycyrrhizin be considered a potential candidate for the treatment of ischemia induced brain damage.

Author Biographies

Chiyeon Lim

College of Medicine, Dongguk University, Ilsandong-gu, Gyeonggi-do, 10326, Republic of Korea

Sehyun Lim

School of Public Health, Far East University, Chungbuk,27601, Republic of Korea.

Young-Jun Lee

Lee Young Jun Clinic of Korean Medicine, Cheonan-si, Chungcheongnam-do,331-963, Republic of Korea

Bokcheul Kong

Samse Oriental Medical Hospital, Gumjeong-gu, Busan-si, 46302, Republic of Korea.

Byoungho Lee

Hongjae Korean Medicine Clinic, Youngdeungpo-gu, Seoul-si, 150051, Republic of Korea

Chang- Hyun Kim

College of Medicine, Dongguk University, Ilsandong-gu, Gyeonggi-do, 10326, Republic of Korea.

Buyeo Kim

Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon,34054, Republic of Korea.

Suin Cho

School of Korean Medicine, Yangsan Campus of Pusan National University, Yangsan-si, 50612, Republic of Korea.

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Published

2017-10-01

How to Cite

Lim, C., Lim, S., Lee, Y.-J., Kong, B., Lee, B., Kim, C.-. H., Kim, B., & Cho, S. (2017). EFFECTS OF GLYCYRRHIZIN PRE-TREATMENT ON TRANSIENT ISCHEMIC BRAIN INJURY IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 14(5), 113–120. https://doi.org/10.21010/ajtcam.v14i5.15

Issue

Vol. 14 No. 5 (2017)

Section

Research Papers

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