DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS

Authors

  • Gabriel O. Anyanwua Department of Biochemistry, Bingham University, Karu, Nasarawa State, Nigeria
  • Chukwu E. Onyeneke Department of Biochemistry, University of Benin, Benin City, Edo State, Nigeria.
  • Patricia Chioma Ofoha Department of Biochemistry, University of Benin, Benin City, Edo State, Nigeria.
  • Khalid Rauf Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad (22060), K.P.K, Pakistan.
  • Usunomena Usunobun Department of Biochemistry, Edo University Iyamho, Edo State, Nigeria
  • Nisar ur-Rehman Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad (22060), K.P.K, Pakistan.

DOI:

https://doi.org/10.21010/ajtcam.vi15.1.7

Keywords:

Anthocleista vogelii, Diuretic, Anti-Diuretic, Laxative, Traditional healers

Abstract

Background: Anthocleista vogelii Planch is a medicinal plant used by traditional healers in the treatment of Malaria, hypertension, ulcer, obesity, diabetes, and as a diuretic and purgative in Africa. Therefore, the present study sought to evaluate the diuretic, antidiuretic and laxative activities of the root bark of A. vogelii extracts and fractions in male Sprague-Dawley rats. Materials and methods: Sixty rats were placed in 10 groups which included: control (normal saline), furosemide/sodium picosulfate (25 mg/kg) as standard drugs, methanol extracts (250 mg/kg and 500 mg/kg), and 125 mg/kg and 250 mg/kg of saponin, flavonoid and neutral alkaloid fractions of A. vogelii. The drugs/extracts/fractions were administered orally using normal saline as the vehicle. Results: The 500 mg/kg methanol extracts (ME) significantly increased (p<0.05) the urine volume and electrolytes (Na+, K+ and Cl-) excreted, while 125 mg/kg and 250 mg/kg flavonoid fraction (FF) decreased significantly (p<0.05) urine volume and electrolytes (Na+, K+ and Cl-) excreted, but doses of saponin fraction (SF) and neutral alkaloid fraction (NAF) had no significant difference (p<0.05) compared to the control after 5 hrs. ME, SF, NAF significantly increased (p<0.05) the fecal output of the animals when compared to the control, while FF showed no significant difference (p<0.05) after 8 hrs of administration. Conclusions: This study determined that ME revealed diuretic activity, although not remarkable to furosemide, while FF showed antidiuretic activity, and potent laxative activities were discovered in ME and SF of A. vogelii.

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Published

2017-12-29

How to Cite

Anyanwua, G. O., Onyeneke, C. E., Ofoha, P. C., Rauf, K., Usunobun, U., & ur-Rehman, N. (2017). DIURETIC, ANTIDIURETIC AND LAXATIVE ACTIVITIES OF ANTHOCLEISTA VOGELII EXTRACTS IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 15(1), 66–73. https://doi.org/10.21010/ajtcam.vi15.1.7

Issue

Vol. 15 No. 1 (2018)

Section

Research Papers

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