ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF PENTACLETHRA MACROPHYLLA AQUEOUS EXTRACTS IN MICE.

Authors

  • C C Okorie Department of Biological Sciences, Michael Okpara University of Agriculture, Umudike, Abia State
  • E N. T. Oparaocha
  • Clement O. Adewunmi
  • E. O. Iwalewa
  • S. K. Omodara

Keywords:

Pentaclethra macrophylla, analgesic, anti-inflammatory, toxicity activities.

Abstract

The aqueous leaf, stem – bark, seed and fruit pericarp extracts of Pentaclethra macrophylla were examined for their cytotoxicity, while only the leaves and seeds were tested for analgesic and anti-inflammatory activities using in-vivo and in-vitro experimental models. Cytotoxicity haemagglutination assay revealed the following order of toxicity among the plant parts: fruit pericarp > stem - bark > seed > leaf with 71.4, 25.6, 5.3, and 0.5 haemagglutination titre values respectively. The extracts at 30 and 60 mg/kg exhibited analgesic activity and anti-inflammatory property using the flick and hot plate tests, acetic acid induced writhing test; and leucocyte counts, pulmonary oedema and oedema paw of mice in a dose-dependent manner. These findings therefore explain and justify ethnomedical uses of Pentaclethra macrophylla in the treatment of itching (inflammatory response) and pain in animals and in man.

Author Biographies

C C Okorie, Department of Biological Sciences, Michael Okpara University of Agriculture, Umudike, Abia State

Department of Biological Sciences, Michael Okpara University of Agriculture, Umudike, Abia State

E N. T. Oparaocha

Department of Biological Sciences, Michael Okpara University of Agriculture, Umudike, Abia State

Clement O. Adewunmi

Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria

E. O. Iwalewa

Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

S. K. Omodara

DRPU, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.

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Published

2006-01-12

How to Cite

Okorie, C. C., Oparaocha, E. N. T., Adewunmi, C. O., Iwalewa, E. O., & Omodara, S. K. (2006). ANTINOCICEPTIVE, ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF PENTACLETHRA MACROPHYLLA AQUEOUS EXTRACTS IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 3(1), 44–53. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/5

Issue

Section

Research Papers

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