SEDATIVE AND ANTICONVULSANT PROPERTIES OF PASSIFLORA EDULIS DRIED LEAVES DECOCTION IN MICE

Authors

  • Elisabeth Ngo Bum
  • Esther Ngah
  • Benoite Charlotte Ekoundi
  • Chriatian Dong
  • Rigobert E. A. Mbomo
  • Silvere Vincent Rakotonirina
  • Alice Rakotonirina

Keywords:

Epilepsy, Anticonvulsant, Decoction, Seizures, Passiflora edulis

Abstract

Passiflora edulis Sims is native from Tropical area of South America. It is used in traditional medicine in the treatment of some diseases related to the nervous system and others. The extract of Passiflora edulis possesses sedative activity in mice. It significantly increased the total sleep time induced by diazepam (50 mg/kg i.p.). The total sleep time increased from 31 + 11 min in the control group to 77.6 + 15 and 78.3 + 16 min in the groups treated with extract at the doses of 132.5 and 1325 mg/kg respectively. This extract showed also anticonvulsant activity in mice. It protected mice against strychnine -induced seizures and antagonized N-methyl-D-aspartate- induced turning behavior in mice. The ED50 for the protection against seizures -induced by strychnine was 320 mg/kg intraperitoneally (i.p.). For N-methyl-D-aspartate -induced turning behavior, the ED50 was 300 mg/kg i.p. Passiflora edulis extract had less effect against pentylene tetrazol- induced seizures. The potentiation of diazepam-induced sleep, the antagonism of chemical -induced seizures and turning behavior suggest that Passiflora edulis extract possess sedative and anticonvulsant properties in animals.

Author Biographies

Elisabeth Ngo Bum

Department of Biological Science, Faculty of Science, University of Ngaoundéré P.O. Box 454 Ngaoundéré, Cameroon

Esther Ngah

National Advanced School of Agro-Industrial Sciences, University of Ngaoundéré P.O. Box 454 Ngaoundéré, Cameroon

Benoite Charlotte Ekoundi

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé, Cameroon

Chriatian Dong

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé, Cameroon

Rigobert E. A. Mbomo

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé, Cameroon

Silvere Vincent Rakotonirina

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé, Cameroon

Alice Rakotonirina

Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé I P.O. Box 812 Yaoundé, Cameroon

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Published

2006-01-07

How to Cite

Bum, E. N., Ngah, E., Ekoundi, B. C., Dong, C., Mbomo, R. E. A., Rakotonirina, S. V., & Rakotonirina, A. (2006). SEDATIVE AND ANTICONVULSANT PROPERTIES OF PASSIFLORA EDULIS DRIED LEAVES DECOCTION IN MICE. African Journal of Traditional, Complementary and Alternative Medicines, 1(1), 63–71. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/66

Issue

Section

Research Papers

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