CHEMICAL AND PHARMACOLOGICAL EVALUATION OF KARPURA SHILAJIT BHASMA, AN AYURVEDIC DIURETIC FORMULATION

Authors

  • A. M. Saleem
  • V. Gopal
  • M. R. S. Rafiullah
  • P. Bharathidasan

Keywords:

Ayurveda, Bhasma, Karpura shilajit bhasma, Shilajit, Diuretic activity

Abstract

In this present study, Karpura shilajit bhasma, an Ayurvedic herbo-mineral formulation, currently used in the Ayurvedic clinical practice as a diuretic drug, was investigated chemically and pharmacologically. Content of iron and nitrogen were determined by volumetric analysis and content of calcium, magnesium and aluminium by Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES). LD50, gross behavioral studies and diuretic activity were evaluated in experimental animals. Calcium was found to be the major element (24.6044% w/w). The LD50 was found to be 4.625 g/kg p.o. body weight in mice. Karpura shilajit bhasma produced mild reduction in motor coordination and mild sedation during the first 2 h after administration at the doses of 500-5000 mg/kg p.o. in mice. The diuretic activity was found to be significant (P < 0.01) at minimum dose of 200 mg/kg p.o. in rats and dose dependant up to 1000 mg/kg p.o. Furthermore, natriuretic effect was found to be significant (P < 0.01), while no significant change was observed on urinary potassium excretion. The present study justified the use of Karpura shilajit bhasma as a diuretic drug. The results of this study could be used as a model data in the standardization of Karpura shilajit bhasma.

Author Biographies

A. M. Saleem

Department of Pharmacognosy, C. L. Baid Metha College of Pharmacy, Thorappakkam, Chennai 600 096, India, 1316

V. Gopal

Department of Pharmacognosy, C. L. Baid Metha College of Pharmacy, Thorappakkam, Chennai 600 096, India, 1316

M. R. S., Rafiullah

Faculty of Pharmacy, Hamdard University, New Delhi 110062, India,

P. Bharathidasan

Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu 613500, India

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Published

2006-01-12

How to Cite

Saleem, A. M., Gopal, V., S., M. R., & Bharathidasan, P. (2006). CHEMICAL AND PHARMACOLOGICAL EVALUATION OF KARPURA SHILAJIT BHASMA, AN AYURVEDIC DIURETIC FORMULATION. African Journal of Traditional, Complementary and Alternative Medicines, 3(2), 27–36. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/74

Issue

Section

Research Papers