THE EFFECT OF MOMORDICA CHARANTIA (BITTER GOURD) EXTRACT ON THE WOUND HEALING IN STREPTOZOTOCIN- INDUCED DIABETIC RATS

Authors

  • S. Das
  • T. Lin
  • A. Latiff

Abstract

The protective action of oral Momordica charantia (MC) extract on diabetes mellitus (DM) has been well documented with fewer studies focusing on its topical use. The aim of the present study was to investigate the healing effect of topical MC extract in comparison with the oral route adminsteration. A total of 108 Sprague Dawley rats were used. The animals were subdivided into two main groups: (i) non-diabetic group (n = 54) and (ii) streptozotocin-induced diabetes (n = 54). These groups were further subdivided into three groups: (i) non-treated control group (n = 18), (ii) topically treated group (n = 18), and (iii) orally treated group (n = 18). Wound was inflicted with a 6 mm punch biopsy needle on the skin of the dorsal thoracolumbar region. The animals were sacrificed on the 1st, 5th and 10th day after wound creation. Rate of wound closure and total protein content were estimated. The histological analysis with light and electron microscopy was performed. There was no significant difference in the total protein content, rate of wound closure and histological changes in the non-diabetic groups. Amongst the diabetic groups, the total protein content and rate of wound closure was significantly increased in the topically treated group in comparison to the non-treated and orally treated groups. Histological observation in the topically treated group showed better integrity of the surface epithelium as compared to the non-treated and orally treated groups. The results showed that wounds of streptozotocin-induced DM healed faster in rats treated with topical MC extract as compared to the oral one.

Author Biography

S. Das

Universiti Kebangsaan Malaysia, Malaysia.

Published

2009-05-04

How to Cite

Das, S., Lin, T., & Latiff, A. (2009). THE EFFECT OF MOMORDICA CHARANTIA (BITTER GOURD) EXTRACT ON THE WOUND HEALING IN STREPTOZOTOCIN- INDUCED DIABETIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 6, 434–435. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/851

Issue

ABSTRACTS OF THE WORLD CONGRESS ON MEDICINAL AND AROMATIC PLANTS, CAPE TOWN NOVEMBER 2008

Section

Conference Abstracts

License

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