PROTECTIVE INFLUENCE OF HIBISCUS SABDARIFFA, AN EDIBLE MEDICINAL PLANT, ON TISSUE LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN HYPERAMMONEMIC RATS

Authors

  • musthafa mohamed essa Dr
  • Perumal P subramanian Dr
  • Thamilarasan T Manivasagam Dr
  • K.B Dakshayani Dr
  • Selvaraju S Subash Mr
  • Ramar R Sivaperumal Mr

Keywords:

Traditional Medicines, Natural Products, Alternative Medicines

Abstract

Abstract The present study was undertaken to examine the protective influence of the alcoholic leaf extract of Hibiscus sabdariffa (Linn) Malvaceae (an indigenous edible medicinal plant used in Ayurvedic and traditional Medicine in India, China and Thailand) (HSEt) on oxidative stress during ammonium chloride induced hyperammonemia by measuring the extent of oxidative damage as well as antioxidant status. The levels of tissue (liver and kidney) lipid peroxides and the antioxidants; superoxide dismutase, catalase, reduced glutathione and glutathione peroxidase were studied in hyperammonemic rats. Hyperammonemia was induced by daily intraperitoneal injections of ammonium chloride at a dose of 100mg/kg body weight for 45 days. Decreased levels of tissue lipid peroxidation accompanied with increased antioxidant levels in hyperammonemic rats were observed during oral administration of HSEt (250mg/kg body weight), which clearly shows the antioxidant property of HSEt. The study of induction of the antioxidant status is considered to be a reliable marker for evaluating the antiperoxidative effect of the medicinal plant. Our present findings show the protective role of HSEt against lipid peroxidation and suggest that HSEt possesses antioxidant potential that may be used for therapeutic purposes. The exact mechanism of action of the extract still has to be investigated and the isolation of its active constituents remains to be done. Keywords: Hibiscus sabdariffa; hyperammonemia; oxidative stress; antioxidants; lipid peroxidation.

Author Biographies

musthafa mohamed essa, Dr

Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

Perumal P subramanian, Dr

Reader Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

Thamilarasan T Manivasagam, Dr

Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

K.B Dakshayani, Dr

Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

Selvaraju S Subash, Mr

Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

Ramar R Sivaperumal, Mr

Department of Biochemistry Faculty of Science Annamalai University Annamalai Nagar – 608 002 Tamil Nadu, India. Tel:+91 4144 238343 ext: 210 Fax:+91 4144 238080

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Published

2006-03-27

How to Cite

essa, musthafa mohamed, subramanian, P. P., Manivasagam, T. T., Dakshayani, K., Subash, S. S., & Sivaperumal, R. R. (2006). PROTECTIVE INFLUENCE OF HIBISCUS SABDARIFFA, AN EDIBLE MEDICINAL PLANT, ON TISSUE LIPID PEROXIDATION AND ANTIOXIDANT STATUS IN HYPERAMMONEMIC RATS. African Journal of Traditional, Complementary and Alternative Medicines, 3(3), 10–21. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/94

Issue

Vol. 3 No. 3 (2006)

Section

Research Papers

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