ANTIBIOTIC SUSCEPTIBILITY PATTERN OF ESCHRICHIA COLI ISOLATES FROM CLINICAL SPECIMENS AT PIMS, ISLAMABAD - Khan, Jafar; Khalil, Irum; AbdEl-Salam, Naser M.; Liaqat, Sehrish; Younas, Naila; Mushtaq, Sameerah; Ullah, Riaz (African Journal of Traditional, Complementary and Alternative Medicines, 2015)
Background: E. coli is the most common producer of extended spectrum beta lactamase enzyme (ESBL) which confers broad spectrum resistance toantibiotics like penicillin, cephalosporin and monobactum.Methods and Materials: The present study was carried out at Pakistan Institute of Medical Sciences, Islamabad. The marked resistance was viewedagainst amoxicilline-clavulanic acid, ceftriaxone and ceftazidime. The most effective drugs established were sulbactum-cefoparazone, amikacin,pepircillin-tazobactum. A total of 220 samples of wide range were selected, i.e., blood, urine, pus, sputum, etc. and were analyzed using varioustechniques of Gram staining and biochemical identification.Results: After performing antibiotic sensitivity tests, 83% samples came out to be ESBL positive and 17% were ESBL negative.Conclusion: It was concluded that to ensure adequate treatment of infections arising especially from urinary pathogens and controlling spread ofbacterial resistant strains, the continuous monitoring by bacterial susceptibility testing is essential.