ANTIBACTERIAL AND WOUND HEALING ACTIVITIES OF MELASTOMA MALABATHRICUM LINN.

Authors

  • Anbu Jeba Sunilson Dr
  • Jisha James lecturer
  • John Thomas lecturer
  • Jayaraj Paulraj lecturer
  • Varatharajan Rajavel lecturer
  • Muthappan Muthu Paliniappan Principal

Keywords:

Melastoma malabathricum, Methanol extract, Wound healing, Wound infection.

Abstract

Melastoma malabathricum Linn. (Melastomataceae), locally known as senduduk putih, is a well-known plant in Malaysian traditional medicine. On the basis of its traditional use and literature reference, this plant was selected for evaluation of its wound healing and antibacterial activities. Methanol extract of M. malabathricum was examined for its wound healing activity in the form of an ointment in two types of wound model in rats: (i) the excision wound model and (ii) the incision wound model. The methanol extract ointment produced a significant response in both of the wound types tested. The results were also comparable with the standard drug, nitrofurazone, in terms of wound contracting ability, wound closure time, tensile strength and regeneration of tissues at the wound site. Regarding antibacterial activity, M. malabathricum extract inhibited the different clinical wound isolates of S. aureus and P. aeruginosa with MIC ranging from 3.0 mg/ml for 3 of the 4 clinical strains of S. aureus to 8.0 mg/ml for all the 3 clinical strains of P. aeruginosa tested.

Author Biographies

Anbu Jeba Sunilson, Dr

Pharmacy, Senior lecturer cum coodinator

Jisha James, lecturer

School of Pharmacy, Master Skill College of Nursing and Health, Battu 9, 43200 Cheras, Selangor, Malaysia

John Thomas, lecturer

School of Pharmacy, Master Skill College of Nursing and Health, Battu 9, 43200 Cheras, Selangor, Malaysia

Jayaraj Paulraj, lecturer

School of Pharmacy, Master Skill College of Nursing and Health, Battu 9, 43200 Cheras, Selangor, Malaysia

Varatharajan Rajavel, lecturer

School of Pharmacy, Master Skill College of Nursing and Health, Battu 9, 43200 Cheras, Selangor, Malaysia

Muthappan Muthu Paliniappan, Principal

School of Pharmacy, Master Skill College of Nursing and Health, Battu 9, 43200 Cheras, Selangor, Malaysia

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Published

2008-11-26

How to Cite

Sunilson, A. J., James, J., Thomas, J., Paulraj, J., Rajavel, V., & Muthu Paliniappan, M. (2008). ANTIBACTERIAL AND WOUND HEALING ACTIVITIES OF MELASTOMA MALABATHRICUM LINN. African Journal of Infectious Diseases (AJID), 2(2), 68–73. Retrieved from https://athmsi.org/journals/index.php/AJID/article/view/391

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Articles