ANTIPROTOZOAL ACTIVITIES OF COMPOUNDS ISOLATED FROM CROTON LOBATUS L

Authors

  • L. Lagnika
  • B. Weniger
  • C. Vonthron-Senecheaub
  • A Sanni

Keywords:

Croton lobatus, tiliroside, vitexin, antiprotozoal activity

Abstract

In a preliminary evaluation of ethnobotanically selected Beninese medicinal plants for their in vitro antiplasmodial activity, the methanolic extract of the aerial parts of C. lobatus was found to have significant activity against P. falciparum, antileishmainal and antiprotoazoal assays carried out on some of the isolated compounds. Phytochemical investigation of this extract resulted in the isolation of five compounds: tiliroside (kaempferol-3-O-β-D-(6-E-p-coumaroyl) glycopyranoside) (1), isovitexin (apigenin-6-C-β-D-glucopyranoside) (2), vitexin (apigenin-8-C- β-D-glucopyranoside) (3), chlorogenic acid (acid-5-O-cafféoylquinic) (4) and 4,5-O-dicaffeoylquinic acid (5). Vitexin and tiliroside showed the best in vitro antiplasmodial activity against P. falciparum, with IC50 values of 4.4 and 7.1 µM, respectively. Vitexin also exhibited strong in vitro leishmanicidal and antitrypanosomal activities against Leishmania donovani amastigotes and Trypanosoma brucei rhodensiense trypomastigotes, with IC50 values of 0.6 and 0.1 µM, respectively.

Author Biographies

L. Lagnika

Laboratoire de Biochimie et de Biologie Moléculaire, Département de Biochimie et de Biologie Cellulaire, Université d’Abomey-Calavi, Cotonou 04 BP 0320, Bénin

B. Weniger

Laboratoire de Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR CNRS-UdS 7200, Faculté de Pharmacie, Université de Strasbourg, France

C. Vonthron-Senecheaub

Laboratoire de Pharmacognosie et Molécules Naturelles Bioactives, Laboratoire d’Innovation Thérapeutique, UMR CNRS-UdS 7200, Faculté de Pharmacie, Université de Strasbourg, France

A Sanni

Laboratoire de Biochimie et de Biologie Moléculaire, Département de Biochimie et de Biologie Cellulaire, Université d’Abomey-Calavi, Cotonou 04 BP 0320, Bénin

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Published

2009-02-19

How to Cite

Lagnika, L., Weniger, B., Vonthron-Senecheaub, C., & Sanni, A. (2009). ANTIPROTOZOAL ACTIVITIES OF COMPOUNDS ISOLATED FROM CROTON LOBATUS L. African Journal of Infectious Diseases (AJID), 3(1), 1–5. Retrieved from https://athmsi.org/journals/index.php/AJID/article/view/556

Issue

Vol. 3 No. 1 (2009)

Section

Articles

License

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