ANTI-DIARRHEAL ACTIVITY AND TOXICITY OF LEARNG PID SAMUD RECIPE

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Parirat Khonsung Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
  • Urarat Nanna Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.
  • Supaporn Vannasiri Division of Physiology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.
  • Nirush Lertprasertsuke Department of Pathology, Faculty of Medicine, Chiang Mai University, Muang, Chiang Mai 50200, Thailand.
  • Tipaya Singhalak Department of Animal Science, Faculty of Agricultural Technology, Chiang Mai Rajabhat University, Chiang Mai, 50300 Thailand.
  • Noppamas Soonthornchareonnon Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
  • Kanjana Jaijoy Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Keywords:

Learng Pid Samud, Anti-diarrheal activity, Acute toxicity, Chronic toxicity

Abstract

Learng Pid Samud (LPS) recipe is a traditional remedy in Thai folk medicine to ease the common diarrhea. The anti-diarrheal potential of LPS recipe was herein examined in vitro using a guinea-pig ileum model. The LPS exerted an inhibitory effect on acetylcholine-induced smooth muscle contraction in the guinea pig ileum. Significantly, not only did the LPS reduce the total amount of feces in the induced diarrhea rats, but also the intestinal transit in the charcoal meal test. A single oral administration with the recipe at 5,000 mg/kg did not cause acute toxicity and the daily oral administration (1,000, 2,000 and 4,000 mg/kg) for 90 days in rats did not produce any toxic signs and symptoms. In conclusion, the Learng Pid Samud recipe remedy is evidently safe and effective for the anti-diarrheal treatment which supports its therapeutic uses in the alternative medicine.

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Published

2012-05-21

How to Cite

Sireeratawong, S., Khonsung, P., Nanna, U., Vannasiri, S., Lertprasertsuke, N., Singhalak, T., Soonthornchareonnon, N., & Jaijoy, K. (2012). ANTI-DIARRHEAL ACTIVITY AND TOXICITY OF LEARNG PID SAMUD RECIPE. African Journal of Traditional, Complementary and Alternative Medicines, 9(4), 519–529. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1517

Issue

Vol. 9 No. 4 (2012)

Section

Research Papers

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