TOXICITY STUDIES OF THE WATER EXTRACT FROM THE CALYCES OF HIBISCUS SABDARIFFA L. IN RATS

Authors

  • Seewaboon Sireeratawong Division of Pharmacology, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Klong 1, Klong Loung, Pathum Thani 12120, Thailand
  • Arunporn Itharat Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120, Thailand
  • Parirat Khonsung Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
  • Nirush Lertprasertsuke Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
  • Kanjana Jaijoy Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand

Keywords:

Hibiscus sabdariffa L., acute toxicity, chronic toxicity

Abstract

Acute and chronic toxicities of the water extract from calyces of Hibiscus sabdariffa were studied in male and female rats. After 14 days of a single oral administration of test substance 5,000 mg/kg body weight, measurement of the body and organ weights, necropsy and health monitoring were performed. No signs and differences of the weights or behaviour compared to the control rats were observed. The results indicated that the single oral administration of H. sabdariffa extract in the amount of 5,000 mg/kg body weight does not produce acute toxicity. The chronic toxicity was determined by oral feeding both male and female rats daily with the extract at the doses of 50, 100, and 200 mg/kg body weight for 270 days. The examinations of signs, animal behaviour and health monitoring showed no defects in the test groups compared to the control groups. Both test and control groups (day 270th) and satellite group (day 298th) were analysed by measuring their final body and organ weights, taking necropsy, and examining haematology, blood clinical chemistry, and microanatomy. Results showed no differences from the control groups. Overall, our study demonstrated that an oral administration of H. sabdariffa extract at the doses of 50, 100 and 200 mg/kg body weight for 270 days does not cause chronic toxicity in rat.

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Published

2013-04-20

How to Cite

Sireeratawong, S., Itharat, A., Khonsung, P., Lertprasertsuke, N., & Jaijoy, K. (2013). TOXICITY STUDIES OF THE WATER EXTRACT FROM THE CALYCES OF HIBISCUS SABDARIFFA L. IN RATS. African Journal of Traditional, Complementary and Alternative Medicines, 10(4), 122–127. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/1593

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Section

Research Papers

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