KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH INHIBITION IN MCF-7 BREAST CANCER CELL

Authors

  • xiaofang yi
  • chao tan The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China;
  • Jiangcheng Zuo Yiling maternity and child health care hospital, Yichang 443003, Hubei, China;
  • Sheng Xian The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China;
  • Chunhua Luo The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China;
  • Sai Chen The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China;
  • Liangfang Yu The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, Hubei, China;
  • Yucheng Luo

DOI:

https://doi.org/10.21010/ajtcam.v13i4.27

Keywords:

Kaempferol, Breast Cancer, Apoptosis.

Abstract

Background: Kaempferol, a natural flavonoid, has been shown to induce cancer cell apoptosis and cell growth inhibition in several tumors. Previously we have conducted a full investigation on the chemical constituents of Gynura medica, kaempferol and its glycosides are the major constituents of G. medica. Here we investigated the growth inhibition and apoptosis induction effect of kaempferol extracted from G. medica. Materials and Methods: The inhibition effects of kaempferol were evaluated by MTS assay and soft agar colony formation assay. Fluorescence staining and western blotting were be used to study the apoptosis. The structure was identified by 1H- NMR), 13C-NMR and ESI-MS analyses. Results: Our results showed that kaempferol’s inhibition of MCF-7 breast cancer cell growth may through inducing apoptosis and downregulation of Bcl2 expression. Conclusion: Kaempferol is a promising cancer preventive and therapeutic agent for breast cancer.

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Published

2016-07-03

How to Cite

yi, xiaofang, tan, chao, Zuo, J., Xian, S., Luo, C., Chen, S., Yu, L., & Luo, Y. (2016). KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH INHIBITION IN MCF-7 BREAST CANCER CELL. African Journal of Traditional, Complementary and Alternative Medicines, 13(4), 210–215. https://doi.org/10.21010/ajtcam.v13i4.27

Issue

Vol. 13 No. 4 (2016)

Section

Research Papers

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