PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA

Authors

  • Maurice Ouedraogo
  • Sylvin Ouedraogo
  • Lamini Ouedraogo
  • Aristide Traore
  • Ramond G. Belemtougri

Keywords:

Extract of Tapinanthus dodoneifolius (Tapidod), Trachea, Calcium.

Abstract

The present study was designed to investigate the blocking of calcium by the hydroalcoholic extract of Tapinanthus dodoneifolius (Tapidod), "in vitro", on rat trachea. To evaluate this effect, the contractile activity of tracheal chains from Wistar Kyoto rats was isometrically recorded. On the isolated tracheal rings the extract produced the following effects: (a) a reduction of the contraction obtained by BaCl2, (b) a bronchorelaxing action, on strips precontracted by KCl, which was not influenced by TEA (3x10-3 M), (c) a concentration-dependent decrease of the spasm evoked by calcium chloride (CaCl2) in K+-rich Ca2+-free physiological salt solution, before and after intracellular calcium depletion (d), an inhibitory effect on contraction induced by acetylcholine in Ca2+-free Krebs-Heinseleit solution supplemented with EDTA (5x10-4M). It is concluded that: 1. The activation of the potassium channels does not play a significant role in the relaxant effect of Tapidod. 2. The antispasmodic property of Tapidod seems to be mediated by the blockade of intracellular Ca2+ release. 3. Most likely an inhibition of the intracellular Ca2+-regulating proteins is involved.

Author Biographies

Maurice Ouedraogo

UFR/SVT,Université de Ouagadougou, 03 BP 7021 Burkina Faso.

Sylvin Ouedraogo

Institut de Recherche en Sciences de la Santé (IRSS/CNRST), BP 7192, Ouagadougou, Burkina Faso. 3UFR/SDS Université de Ouagadougou, 03 BP 7021, Burkina Faso

Lamini Ouedraogo

UFR/SVT,Université de Ouagadougou, 03 BP 7021 Burkina Faso

Aristide Traore

Institut de Recherche en Sciences de la Santé (IRSS/CNRST), BP 7192, Ouagadougou, Burkina Faso. 3UFR/SDS Université de Ouagadougou, 03 BP 7021, Burkina Faso.

Ramond G. Belemtougri

UFR/SVT,Université de Ouagadougou, 03 BP 7021 Burkina Faso

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Published

2006-01-07

How to Cite

Ouedraogo, M., Ouedraogo, S., Ouedraogo, L., Traore, A., & Belemtougri, R. G. (2006). PHARMACOLOGICAL EVALUATIONS FOR THE RELAXANT EFFECT OF THE HYDROALCOHOLIC EXTRACT OF TAPINANTHUS DODONEIFOLIUS ON RAT TRACHEA. African Journal of Traditional, Complementary and Alternative Medicines, 2(2), 166 –. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/49

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Section

Research Papers

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