CARDIOVASCULAR PROPERTIES OF AQUEOUS EXTRACT FROM TAPINANTHUS DODONEIFOLIUS DC DANSER.

Authors

  • Sylvin Ouedraogo
  • Aristide Traore
  • N. Some
  • M. Lompo
  • P. I. Guissoe
  • Christa Scott
  • Bernard Bucher
  • Ramaroson Andriantsitohaina

Keywords:

Tapinanthus dodoneifolius, endothelium, vasodilator, rat.

Abstract

Aqueous extracts of Tapinanthus dodoneifolius DC Danser. (Loranthaceae) (AETD) were investigated for cardiovascular activities on isolated rat aorta and heart. AETD did not affect heart rate but significantly enhanced heart contraction force and relaxation capacity. AETD (0.001-1mg/ml) elicited a dose-dependent relaxation on arteries which was previously contracted with phenylephrine [10-6M] (rat aorta). AETD induces relaxation in endothelium dependent manner. When Indomethacin failed to inhibit AETD vasodilatory activity, in the presence of L-NAME, the vasodilatory activity of AETD was completely abolished. These results suggest a cardiotropic activity without any tachycardia as a side effect for AETD. However, AETD elicited vasodilatory activity which involved NO from endothelium.

Author Biographies

Sylvin Ouedraogo

Institut de Recherche en Sciences de la Santé (IRSS/CNRST) 01BP 7192 Ouagadougou 01 Burkina Faso and

Aristide Traore

Institut de Recherche en Sciences de la Santé (IRSS/CNRST) 01BP 7192 Ouagadougou 01 Burkina Faso and

N. Some

Institut de Recherche en Sciences de la Santé (IRSS/CNRST) 01BP 7192 Ouagadougou 01 Burkina Faso and

M. Lompo

Institut de Recherche en Sciences de la Santé (IRSS/CNRST) 01BP 7192 Ouagadougou 01 Burkina Faso and

P. I. Guissoe

Institut de Recherche en Sciences de la Santé (IRSS/CNRST) 01BP 7192 Ouagadougou 01 Burkina Faso and

Christa Scott

bLaboratoire de Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, UMR 7034 CNRS, Faculté de Pharmacie, 67401 Illkirch, France.

Bernard Bucher

bLaboratoire de Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, UMR 7034 CNRS, Faculté de Pharmacie, 67401 Illkirch, France.

Ramaroson Andriantsitohaina

bLaboratoire de Pharmacologie et Physico-Chimie des Interactions Cellulaires et Moléculaires, Université Louis Pasteur de Strasbourg, UMR 7034 CNRS, Faculté de Pharmacie, 67401 Illkirch, France.

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Published

2006-01-07

How to Cite

Ouedraogo, S., Traore, A., Some, N., Lompo, M., Guissoe, P. I., Scott, C., Bucher, B., & Andriantsitohaina, R. (2006). CARDIOVASCULAR PROPERTIES OF AQUEOUS EXTRACT FROM TAPINANTHUS DODONEIFOLIUS DC DANSER. African Journal of Traditional, Complementary and Alternative Medicines, 2(1), 25–30. Retrieved from https://athmsi.org/journals/index.php/ajtcam/article/view/55

Issue

Vol. 2 No. 1 (2005)

Section

Research Papers

License

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